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Double Mutant Covid Variant Leads to “Modest” Loss of Antibody Neutralization: IGIB Chief | India News


NEW DELHI: Coronavirus variant B.1.617, also known as ‘double mutant’, leads to loss of antibody neutralization, but is modest, Anurag Agrawal, director of the Institute for Genomics and Integrative Biology, said Tuesday, noting that the vaccines are effective against it.
The research, of which Agrawal was a part, also suggested that vaccines are likely to prevent serious diseases.
B.1.617 has three spike protein mutations. Two mutations E484Q and L452R are in the area important for antibody-based neutralization. The third P681R mutation allows the virus to enter cells a little better.
“The loss of neutralization capacity of the antibodies is modest but not much. It is not the case that the double mutation has twice the loss of neutralization. There is loss of neutralization but it is not a large amount. We are waiting for the vaccines to continue working. even if they work a little less. They should prevent serious illnesses, “Agrawal said.
The document has not yet been peer-reviewed, he said.
A manual published by the Office of the Chief Scientific Advisor last week said that Covaxin and Covishield, two vaccines currently in use in India, provide protection against the B.1.617 variant of the virus.
“Vaccination campaigns in some countries have resulted in 95.8

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